Recovery in humans of intravenously injected isotopic uric acid.
نویسندگان
چکیده
It is presumed that uric acid is an end-product of human metabolism and, as such, is not further catabolized. This presumption is based largely upon indirect evidence such as the failure to demonstrate uricase in human tissues and the uncertain r81e of allantoin in human metabolism. On the other hand, Folin presented evidence that uric acid intravenously injected into humans could not be quantitatively recovered (1). More recently Benedict et al., using N15-labeled uric acid, estimated that only approximately 79 per cent of the uric acid “turned over” by the body each day was excreted in the urine. Furthermore, an appreciable concentrat.ion of N15 from the injected uric acid was occasionally found in other “catabolic” fragments such as urea (2). Geren et al. (3), however, claimed nearly quantitative recovery of an intravenous dose of N15-uric acid.’ Because of the uncertainty associated with the usual calorimetric methods for uric acid determination, it was considered pertinent to determine the per cent recovery in the urine of intravenously injected isotopic uric acid with the isotope dilution procedure.2
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 196 1 شماره
صفحات -
تاریخ انتشار 1952